Intravenous <i>versus</i> Volatile Anesthetic Effects on Postoperative Cognition in Elderly Patients Undergoing Laparoscopic Abdominal Surgery

Background Delayed neurocognitive recovery after surgery is associated with poor outcome. Most surgeries require general anesthesia, of which sevoflurane and propofol are the most commonly used inhalational intravenous anesthetics. The authors tested primary hypothesis that patients laparoscopic abdominal under propofol-based anesthesia have a lower incidence delayed than sevoflurane-based anesthesia. A second there were blood biomarkers for predicting to occur. Methods randomized, double-blind, parallel, controlled study was performed at four hospitals in China. Elderly (60 yr older) undergoing likely longer 2 h randomized propofol- or regimen maintain minimum 221 planned each group detect one-third decrease compared group. outcome 5 7 days surgery. Results total 544 enrolled, 272 Of these patients, 226 completed needed neuropsychological tests diagnosing recovery, 46 (20.8%) 38 (16.8%) met criteria (odds ratio, 0.77; 95% CI, 0.48 1.24; P = 0.279). high interleukin-6 concentration 1 skin incision an increased likelihood 1.04; 1.01 1.07; 0.007). Adverse event incidences similar both groups. Conclusions Anesthetic choice between did not appear affect surgical may be independent risk factor recovery. Editor’s Perspective What We Already Know about This Topic Article Tells Us That Is New